Debt Securities, Available-for-sale [Abstract] Amortized Cost Debt Securities, Available-for-sale, Amortized Cost, Fiscal Year Maturity [Abstract] Less than one year Debt Securities, Available-for-sale, Maturity, Remainder of Fiscal Year, Amortized Cost Greater than one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling after One Through Five Years, Amortized Cost Cost Debt Securities, Available-for-sale, Amortized Cost Estimated Fair Value Debt Securities, Available-for-sale, Fair Value, Fiscal Year Maturity [Abstract] Less than one year Debt Securities, Available-for-sale, Maturity, Remainder of Fiscal Year, Fair Value Greater than one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling after One Through Five Years, Fair Value Total estimated fair value Debt Securities, Available-for-sale Leases [Abstract] Operating Leases Lessee, Operating Leases [Text Block] Equity [Abstract] Schedule of Stock Option Activity Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of Restricted Stock Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Schedule of Available-for-sale Securities Reconciliation Schedule of Available-for-sale Securities Reconciliation [Table Text Block] Schedule of Marketable Securities Marketable Securities [Table Text Block] Investments Classified by Contractual Maturity Date Investments Classified by Contractual Maturity Date [Table Text Block] Share-based Compensation [Abstract] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Income Statement Location [Axis] Income Statement Location [Axis] Total share-based compensation expense Income Statement Location [Domain] Research and Development [Member] Research and Development Expense [Member] General and Administrative [Member] Selling, General and Administrative Expenses [Member] Award Type [Axis] Award Type [Axis] Award Type [Domain] Equity Award [Domain] Stock Option [Member] Employee Stock Option [Member] Restricted Stock [Member] Restricted Stock [Member] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based compensation expense Allocated Share-based Compensation Expense Unrecognized compensation cost Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Expected weighted-average period in years of compensation cost to be recognized Share-based Goods and Nonemployee Services Transaction, Valuation Method, Expected Term Total fair value of shares vested Adjustments to Additional Paid in Capital, Share-based Compensation, Stock Options, Requisite Service Period Recognition Weighted average estimated fair value of shares granted Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price Cash and cash equivalents Cash Marketable securities Marketable Securities Total Cash, Cash Equivalents, and Short-term Investments Finance Minimum Lease Payments Finance Lease Liabilities, Payments, Due [Abstract] 2019 Lessee, Operating Lease, Liability, Payments, Remainder of Fiscal Year 2020 Lessee, Operating Lease, Liability, Payments, Due Year Two 2021 Lessee, Operating Lease, Liability, Payments, Due Year Three 2022 Lessee, Operating Lease, Liability, Payments, Due Year Four 2023 Lessee, Operating Lease, Liability, Payments, Due Year Five Total lease payments Lessee, Operating Lease, Liability, Payments, Due Less: Amounts representing interest Finance Lease, Liability, Undiscounted Excess Amount Present value of lease liabilities Operating Lease, Liability Statement of Comprehensive Income [Abstract] Net loss Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Available for sale securities - net unrealized income (loss) Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax Total other comprehensive income (loss) Other Comprehensive Income (Loss), Net of Tax Comprehensive loss Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest Comprehensive income (loss) attributable to noncontrolling interests Comprehensive Income (Loss), Net of Tax, Attributable to Noncontrolling Interest Comprehensive loss attributable to Caladrius Biosciences, Inc. common stockholders Comprehensive Income (Loss), Net of Tax, Attributable to Parent Accounting Policies [Abstract] Concentration of Risks Concentration Risk, Credit Risk, Policy [Policy Text Block] Share-Based Compensation Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Income Taxes Income Tax, Policy [Policy Text Block] Recently Issued Accounting Pronouncement New Accounting Pronouncements, Policy [Policy Text Block] Number of restricted stock issued Stock Issued During Period, Shares, Restricted Stock Award, Gross Value of restricted stock issued ($ in thousands) Stock Issued During Period, Value, Restricted Stock Award, Gross Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Adjustments for New Accounting Pronouncements [Axis] Adjustments for New Accounting Pronouncements [Axis] Type of Adoption [Domain] Type of Adoption [Domain] ASU No. 2016-02 - Topic 842 Accounting Standards Update 2016-02 [Member] Lessee, Lease, Description [Line Items] Lessee, Lease, Description [Line Items] Number of offices under operating leases Number Of Offices Under Operating Leases Number Of Offices Under Operating Leases Operating lease liabilities Operating lease right-of-use assets Operating Lease, Right-of-Use Asset Weighted average remaining lease term for operating leases (in years) Operating Lease, Weighted Average Remaining Lease Term Weighted average discount rate for operating leases (percent) Operating Lease, Weighted Average Discount Rate, Percent Available-for-Sale Securities Cash, Cash Equivalents, and Marketable Securities [Text Block] Fair Value Disclosures [Abstract] Schedule of Assets Measured at Fair Value on Recurring Basis Fair Value, Assets Measured on Recurring Basis [Table Text Block] Schedule of Stockholders' Equity Note, Stock Options and warrants [Table] Class of Warrant or Right [Table] Stock Options Activity [Axis] Stock Options Activity [Axis] Stock Options Activity [Axis] Stock Options Activity [Domain] Stock Options Activity [Domain] Stock Options Activity [Domain] US Equity Plan [Member] US Equity Plan [Member] US Equity Plan [Member] Stock Options and Warrants [Line Items] Class of Warrant or Right [Line Items] Stock Options Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest [Abstract] Options, Outstanding [Roll Forward] Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Options, Outstanding, Beginning of Period Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Options, Grants in Period, Net of Forfeitures Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures Options, Exercises in Period Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Options, Forfeitures in Period Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Options, Expirations in Period Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period Options, Outstanding, End of Period Options, Outstanding, Weighted Average Exercise Price [Abstract] Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Options, Outstanding, Weighted Average Exercise Price, Beginning of Period Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Options, Grants in Period, Weighted Average Exercise Price Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Options, Exercises in Period, Weighted Average Exercise Price Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Options, Forfeitures in Period, Weighted Average Exercise Price Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Options, Expirations in Period, Weighted Average Exercise Price Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price Options, Outstanding, Weighted Average Exercise Price, End of Period Options, Outstanding, Weighted Average Remaining Contractual Term Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Options, Outstanding, Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Options, Vested and Expected to Vest, Outstanding, Number Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Options, Vested and Expected to Vest, Exercisable, Number Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price Options, Vested, Weighted Average Remaining Contractual Term Options, Vested, weighted Average Remaining Contractual Term Options, Vested, weighted Average Remaining Contractual Term Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value Warrants Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Additional Disclosures [Abstract] Warrants, Number of Shares [Roll Forward] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Warrants, Shares, Beginning of Period Common Stock Warrants, Shares Common Stock Warrants, Shares Warrants Granted Warrants Granted Warrants Granted Warrants Exercised Warrants Exercised Warrants Exercised Warrants Canceled Warrants Canceled Warrants Canceled Warrants Expired Warrants Expired Warrants Expired Warrants, Shares, End of Period Warrants Weighted Average Exercise Price [Roll Forward] Warrants Weighted Average Exercise Price [Roll Forward] Warrants Weighted Average Exercise Price [Roll Forward] Weighted Average Exercise Price, Warrants Outstanding, Beginning of Period Weighted Average Exercise Price, Warrants Outstanding Weighted Average Exercise Price, Warrants Outstanding Weighted Average Exercise Price, Warrants Granted Weighted Average Exercise Price, Warrants Granted Weighted Average Exercise Price, Warrants Granted Weighted Average Exercise Price, Warrants Exercised Weighted Average Exercise Price, Warrants Exercised Weighted Average Exercise Price, Warrants Exercised Weighted Average Exercise Price, Warrants Canceled Weighted Average Exercise Price, Warrants Canceled Weighted Average Exercise Price, Warrants Canceled Weighted Average Exercise Price, Warrants Expired Weighted Average Exercise Price, Warrants Expired Weighted Average Exercise Price, Warrants Expired Weighted Average Exercise Price, Warrants Outstanding, End of Period Weighted Average Remaining Contractual Term, Warrant outstanding Weighted Average Remaining Contractual Term warrant outstanding Weighted Average Remaining Contractual Term warrant outstanding Aggregate Intrinsic Value, Warrants Outstanding Aggregate Intrinsic Value, Warrants Outstanding Aggregate Intrinsic Value, Warrants Outstanding Warrants, vested and expected to vest shares, vested and expected to vest shares, vested and expected to vest Weighted Average Exercise Price, Warrants vested & expected to vest Weighted Average Exercise Price, Warrants vested & expected to vest Weighted Average Exercise Price, Warrants vested & expected to vest Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest Aggregate Intrinsic Value, Warrants vested and expected to vest Aggregate Intrinsic Value, Warrants vested and expected to vest Aggregate Intrinsic Value, Warrants vested and expected to vest Warrants, Vested. Number Warrants, Vested Warrants, Vested Warrants, Vested, Weighted Average Exercise Price Weighted Average Exercise Price, Warrants Exercisable Weighted Average Exercise Price, Warrants Exercisable Warrants, Vested, Weighted Average Remaining Contractual Term weighted Average Remaining Contractual Term, warrants vested weighted Average Remaining Contractual Term, warrants vested Warrants, Vested, Aggregate Intrinsic Value Aggregate Intrinsic Value, Warrants vested Aggregate Intrinsic Value, Warrants vested Document and Entity Information [Abstract] Document and Entity Information [Abstract] Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Document Type Document Type Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Amendment Flag Amendment Flag Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Earnings Per Share [Abstract] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] The Business The Business [Text Block] The Business [Text Block] Statement of Cash Flows [Abstract] Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Share-based compensation Issuance of Stock and Warrants for Services or Claims Depreciation and amortization Depreciation, Depletion and Amortization, Nonproduction Accretion on marketable securities Accretion (Amortization) of Discounts and Premiums, Investments Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Prepaid and other current assets Increase (Decrease) in Prepaid Expense and Other Assets Other assets Increase (Decrease) in Other Operating Assets Accounts payable, accrued liabilities and other liabilities Increase Decrease In Accounts Payable Accrued Expenses And Other Liabilities Increase Decrease In Accounts Payable Accrued Expenses And Other Liabilities Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Purchase of marketable securities Payments to Acquire Marketable Securities Sale of marketable securities Proceeds from Sale and Maturity of Marketable Securities Acquisition of property and equipment Payments to Acquire Property, Plant, and Equipment Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Investing Activities Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Proceeds from exercise of options Proceeds from Stock Options Exercised Tax withholding payments on net share settlement equity awards Payments Related to Tax Withholding for Share-based Compensation Net proceeds from issuance of common stock Proceeds from Issuance or Sale of Equity Repayment of notes payable Repayments of Notes Payable Net cash provided by (used in) financing activities Net Cash Provided by (Used in) Financing Activities Net increase (decrease) in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Cash, cash equivalents and restricted cash at beginning of period Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash, cash equivalents and restricted cash at end of period Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Supplemental Disclosure of Cash Flow Information: Supplemental Cash Flow Information [Abstract] Cash paid during the period for: Interest Paid, Including Capitalized Interest, Operating and Investing Activities [Abstract] Interest Interest Paid, Excluding Capitalized Interest, Operating Activities Share-Based Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Schedule of Available-for-sale Securities [Table] Schedule of Available-for-sale Securities [Table] Financial Instrument [Axis] Financial Instrument [Axis] Financial Instruments [Domain] Financial Instruments [Domain] Money Market Funds [Member] Money Market Funds [Member] Corporate Debt Securities [Member] Corporate Debt Securities [Member] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-sale [Line Items] Gross Unrealized Gains Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Gross Unrealized Losses Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Estimated Fair Value Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Table] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Fair Value, Measurements, Fair Value Hierarchy [Domain] Fair Value Hierarchy and NAV [Domain] Level 1 Fair Value, Inputs, Level 1 [Member] Level 2 Fair Value, Inputs, Level 2 [Member] Level 3 Fair Value, Inputs, Level 3 [Member] Measurement Frequency [Axis] Measurement Frequency [Axis] Fair Value, Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Fair Value, Measurements, Recurring [Member] Fair Value, Measurements, Recurring [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Marketable securities - available for sale Investments, Fair Value Disclosure Assets, fair value disclosure Assets, Fair Value Disclosure Statement of Financial Position [Abstract] Preferred stock, shares authorized Preferred Stock, Shares Authorized Preferred stock, Series B convertible redeemable preferred stock liquidation value, share of common stock Convertible Preferred Stock, Shares Issued upon Conversion Preferred stock, par value (in usd per share) Preferred Stock, Par or Stated Value Per Share Preferred stock, shares designated Preferred stock, shares designated Preferred stock, shares designated Preferred stock, shares issued Preferred Stock, Shares Issued Preferred stock, shares outstanding Preferred Stock, Shares Outstanding Common stock, par value (in usd per share) Common Stock, Par or Stated Value Per Share Common stock, shares authorized Common Stock, Shares Authorized Common stock, shares issued Common Stock, Shares, Issued Common stock, shares, outstanding Common Stock, Shares, Outstanding Treasury stock (shares) Treasury Stock, Shares Research Funding [Abstract] Research Funding [Abstract] Deferred Revenue Arrangement, by Type [Table] Deferred Revenue Arrangement, by Type [Table] Balance Sheet Location [Axis] Balance Sheet Location [Axis] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Accrued Liabilities [Member] Accounts Payable and Accrued Liabilities [Member] Other Long-Term Liabilities [Member] Other Noncurrent Liabilities [Member] Income Statement Location [Domain] Deferred Revenue Arrangement [Line Items] Deferred Revenue Arrangement [Line Items] Grants awarded Grants Receivable Funding of grant award Funding Of Grant Award, Cash Received Funding Of Grant Award, Cash Received Milestone payment received on grant award Milestone Payment On Grant Award, Cash Received Milestone Payment On Grant Award, Cash Received Progress payment received on grant award Progress Payment On Grant Award, Cash Received Progress Payment On Grant Award, Cash Received Accrued grant funding Accrued Grant Funding Accrued Grant Funding Amortization of accrued grant funding to offset expense Amortization Of Accrued Grant Funding Liability To Offset Expense Amortization Of Accrued Grant Funding Liability To Offset Expense Accrued Liabilities [Abstract] Accrued Liabilities Accounts Payable and Accrued Liabilities Disclosure [Text Block] Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Project [Axis] Project [Axis] Project [Domain] Project [Domain] Ischemic Repair (CD34 Cell Technology) [Member] Ischemic Repair CD34 Cell Technology [Member] Ischemic Repair CD34 Cell Technology [Member] Research and Development Arrangement, Contract to Perform for Others [Line Items] Research and Development Arrangement, Contract to Perform for Others [Line Items] Salaries, employee benefits and related taxes Employee-related Liabilities Operating lease liabilities - current Retention Payable CIRM upfront funding - current Customer Advances, Current Other Other Accrued Liabilities Total accrued liabilities Accrued Liabilities ASSETS Assets [Abstract] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Prepaid and other current assets Prepaid Expense and Other Assets, Current Total current assets Assets, Current Property and equipment, net Property, Plant and Equipment, Net Other assets Other Assets, Noncurrent Total assets Assets LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities and Equity [Abstract] Liabilities Liabilities [Abstract] Accounts payable Accounts Payable, Current Accrued liabilities Accrued Liabilities, Current Total current liabilities Liabilities, Current Other long-term liabilities Other Liabilities, Noncurrent Total liabilities Liabilities Commitments and Contingencies Commitments and Contingencies STOCKHOLDERS' EQUITY Stockholders' Equity Stockholders' Equity Attributable to Parent [Abstract] Preferred stock, authorized, 20,000,000 shares Series B convertible redeemable preferred stock liquidation value, 1 share of common stock, $0.01 par value; 825,000 shares designated; issued and outstanding, 10,000 shares at March 31, 2019 and December 31, 2018, respectively Preferred Stock, Value, Issued Common stock, $0.001 par value, authorized 500,000,000 shares; issued and outstanding, 10,393,312 and 9,865,735 shares at March 31, 2019 and December 31, 2018, respectively Common Stock, Value, Issued Additional paid-in capital Additional Paid in Capital Treasury stock, at cost; 11,080 shares at March 31, 2019 and December 31, 2018 Treasury Stock, Value Accumulated deficit Retained Earnings (Accumulated Deficit) Accumulated other comprehensive loss Accumulated Other Comprehensive Income (Loss), Net of Tax Total Caladrius Biosciences, Inc. stockholders' equity Stockholders' Equity Attributable to Parent Noncontrolling interests Stockholders' Equity Attributable to Noncontrolling Interest Total stockholders' equity Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest Liabilities and Equity, Total Liabilities and Equity Loss Per Share Earnings Per Share [Text Block] Commitments and Contingencies Disclosure [Abstract] Contingencies Commitments and Contingencies Disclosure [Text Block] Other Assets [Member] Other Assets [Member] Accrued Liabilities [Member] Accrued Liabilities [Member] Balance Sheet Captions Assets and Liabilities, Lessee [Abstract] Right-of-use assets Operating lease liabilities, current Operating Lease, Liability, Current Operating lease liabilities, noncurrent Operating Lease, Liability, Noncurrent Operating lease liabilities Schedule Share-based Compensation Expense Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Schedule of Total Compensation Cost Related to Nonvested Awards Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block] Schedule of Fair Value of Share-based Compensation Awards Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of Accrued Liabilities Schedule of Accrued Liabilities [Table Text Block] Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] Schedule of Operating Lease Liabilities and Right-of-Use Assets on Balance Sheet Lessee, Operating Lease, Balance Sheet Presentation [Table Text Block] Lessee, Operating Lease, Balance Sheet Presentation [Table Text Block] Schedule of Future Minimum Lease Payments Under Lease Agreements Lessee, Operating Lease, Liability, Maturity [Table Text Block] Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Statement of Stockholders' Equity [Abstract] Statement [Table] Statement [Table] Statement, Equity Components [Axis] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Total Caladrius Biosciences, Inc. Stockholders' Equity Parent [Member] Series B Convertible Preferred Stock Preferred Stock [Member] Common Stock Common Stock [Member] Additional Paid in Capital Additional Paid-in Capital [Member] Accumulated Other Comprehensive Loss AOCI Attributable to Parent [Member] Accumulated Deficit Retained Earnings [Member] Treasury Stock Treasury Stock [Member] Non- Controlling Interest in Subsidiary Noncontrolling Interest [Member] Class of Stock [Axis] Class of Stock [Axis] Class of Stock [Domain] Class of Stock [Domain] Series B Convertible Preferred Stock Series B Preferred Stock [Member] Statement [Line Items] Statement [Line Items] Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Beginning Balance (shares) Shares, Outstanding Beginning Balance Adoption of accounting standard New Accounting Pronouncement or Change in Accounting Principle, Effect of Adoption, Quantification Unrealized loss on marketable securities Other Comprehensive Income (Loss), Securities, Available-for-sale, Adjustment, after Tax Share-based compensation (in shares) Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Share-based compensation Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Net proceeds from issuance of common stock (in shares) Stock Issued During Period, Shares, New Issues Net proceeds from issuance of common stock Stock Issued During Period, Value, New Issues Proceeds from option exercises (in shares) Proceeds from option exercises Stock Issued During Period, Value, Stock Options Exercised Change in ownership in subsidiary Change in Ownership in Subsidiary Change in Ownership in Subsidiary Ending Balance (shares) Ending Balance Fair Value Measurements Fair Value Disclosures [Text Block] Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Disposal Group Name [Axis] Disposal Group Name [Axis] Disposal Group Name [Domain] Disposal Group Name [Domain] Disposal Group Classification [Axis] Disposal Group Classification [Axis] Disposal Group Classification [Domain] Disposal Group Classification [Domain] Legal Entity [Axis] Legal Entity [Axis] Entity [Domain] Entity [Domain] Counterparty Name [Axis] Counterparty Name [Axis] Counterparty Name [Domain] Counterparty Name [Domain] Subsidiary, Sale of Stock [Line Items] Subsidiary, Sale of Stock [Line Items] Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Table] Income Tax Authority [Axis] Income Tax Authority [Axis] Income Tax Authority [Domain] Income Tax Authority [Domain] Federal [Member] Domestic Tax Authority [Member] Operating Loss Carryforwards [Line Items] Operating Loss Carryforwards [Line Items] Operating loss carryforwards Operating Loss Carryforwards Market capitalization used in net operating loss analysis Market Capitalization Used In Net Operating Loss Analysis Market Capitalization Used In Net Operating Loss Analysis Annual limitation on usage of net operating losses Net Operating Loss Analysis, Annual Limitation Net Operating Loss Analysis, Annual Limitation Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Warrant [Member] Warrant [Member] Restricted Stock Units (RSUs) [Member] Restricted Stock Units (RSUs) [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive securities excluded from computation of earnings per share Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Income Statement [Abstract] Operating Expenses: Operating Expenses [Abstract] Research and development Research and Development Expense General and administrative Selling, General and Administrative Expense Total operating expenses Operating Expenses Operating loss Operating Income (Loss) Other income (expense): Nonoperating Income (Expense) [Abstract] Investment income, net Other Nonoperating Income (Expense) Interest expense Interest Expense Total other income (expense), net Nonoperating Income (Expense) Net loss Less - net income (loss) attributable to noncontrolling interests Income (Loss) from Continuing Operations, Net of Tax, Attributable to Noncontrolling Interest Net (loss) income attributable to Caladrius Biosciences, Inc. common stockholders Net Income (Loss) Available to Common Stockholders, Basic Basic and diluted loss per share Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract] Caladrius Biosciences, Inc. common stockholders (in usd per share) Earnings Per Share, Basic and Diluted Weighted average common shares outstanding Weighted Average Number of Shares Outstanding, Diluted [Abstract] Basic and diluted shares Weighted Average Number of Shares Outstanding, Basic and Diluted Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Sale of Stock [Axis] Sale of Stock [Axis] Sale of Stock, Name of Transaction [Domain] Sale of Stock [Domain] H.C. Wainwright Sales Agreement [Member] H.C. Wainwright Sales Agreement [Member] H.C. Wainwright Sales Agreement [Member] H.C. Wainwright Sales Amended Agreement [Member] H.C. Wainwright Sales Amended Agreement [Member] H.C. Wainwright Sales Amended Agreement [Member] Class of Stock [Line Items] Class of Stock [Line Items] Stock issued (shares) Proceeds from issuance of stock Proceeds from Issuance of Common Stock Aggregate offering amount authorized per agreement Sale Of Stock, Aggregate Offering Amount Authorized Per Agreement Sale Of Stock, Aggregate Offering Amount Authorized Per Agreement Maximum number of shares authorized per agreement Sale Of Stock, Maximum Number Of Shares Authorized Per Agreement Sale Of Stock, Maximum Number Of Shares Authorized Per Agreement Commission on gross proceeds due to third party (percent) Sale Of Stock, Commission On Gross Proceeds Due To Third Party Upon, Percent Sale Of Stock, Commission On Gross Proceeds Due To Third Party Upon, Percent Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Research Funding Research, Development, and Computer Software Disclosure [Text Block]