Accrued Liabilities [Abstract] Schedule of Accrued Liabilities Schedule of Accrued Liabilities [Table Text Block] Income Statement [Abstract] Research and development Research and Development Expense General, and administrative Selling, General and Administrative Expense Operating expenses Operating Expenses Operating loss Operating Income (Loss) Other income (expense): Nonoperating Income (Expense) [Abstract] Other income, net Other Nonoperating Income (Expense) Interest expense Interest Expense Total other income (expense), net Nonoperating Income (Expense) Net loss Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Less - net income (loss) attributable to noncontrolling interests Income (Loss) from Continuing Operations, Net of Tax, Attributable to Noncontrolling Interest Net loss attributable to Caladrius Biosciences, Inc. common shareholders Net Income (Loss) Attributable to Parent Basic and diluted loss per share: Earnings Per Share, Basic and Diluted [Abstract] Basic and diluted loss per share attributable to Caladrius Biosciences, Inc. common stockholders (in dollars per share) Earnings Per Share, Basic and Diluted Weighted average common shares outstanding: Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract] Basic and diluted weighted average common shares outstanding (shares) Weighted Average Number of Shares Outstanding, Basic and Diluted Property, Plant and Equipment [Abstract] Schedule of Property and Equipment Property, Plant and Equipment [Table Text Block] Commitments and Contingencies Disclosure [Abstract] Contingencies Commitments and Contingencies Disclosure [Text Block] Leases [Abstract] Schedule of Operating Lease Liabilities and Right-of-Use Assets on Balance Sheet Lessee, Operating Lease, Balance Sheet Presentation [Table Text Block] Lessee, Operating Lease, Balance Sheet Presentation [Table Text Block] Schedule of Future Minimum Lease Payments Under Lease Agreements Lessee, Operating Lease, Liability, Maturity [Table Text Block] Equity [Abstract] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Award Type [Axis] Award Type [Axis] Award Type [Domain] Award Type [Domain] Restricted Stock Restricted Stock [Member] Restricted Stock Units Restricted Stock Units (RSUs) [Member] Statistical Measurement [Axis] Statistical Measurement [Axis] Statistical Measurement [Domain] Statistical Measurement [Domain] Minimum Minimum [Member] Maximum Maximum [Member] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Restricted Stock and Restricted Stock Units Restricted Stock And Restricted Stock Units Issued [Abstract] Restricted Stock And Restricted Stock Units Issued [Abstract] Number of shares issued (shares) Stock Issued During Period, Shares, Restricted Stock Award, Gross Value of shares issued Stock Issued During Period, Value, Restricted Stock Award, Gross Weighted average estimated fair value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Vesting terms (in years) Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Accounting Policies [Abstract] Schedule of Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Furniture and fixtures Furniture and Fixtures [Member] Computer equipment Computer Equipment [Member] Software Software and Software Development Costs [Member] Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Useful life (in years) Property, Plant and Equipment, Useful Life Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Adjustments for New Accounting Pronouncements [Axis] Adjustments for New Accounting Pronouncements [Axis] Type of Adoption [Domain] Type of Adoption [Domain] ASU 2016-02 Topic 842 Accounting Standards Update 2016-02 [Member] Lessee, Lease, Description [Line Items] Lessee, Lease, Description [Line Items] Number of office under operating leases Number Of Offices Under Operating Leases Number Of Offices Under Operating Leases Operating lease liabilities Operating Lease, Liability Right-of-use assets Operating Lease, Right-of-Use Asset Weighted average remaining lease term for operating leases (in years) Operating Lease, Weighted Average Remaining Lease Term Weighted average discount rate for operating leases (percent) Operating Lease, Weighted Average Discount Rate, Percent Research and Development [Abstract] Deferred Revenue Arrangement, by Type [Table] Deferred Revenue Arrangement, by Type [Table] Balance Sheet Location [Axis] Balance Sheet Location [Axis] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Accrued Liabilities Accounts Payable and Accrued Liabilities [Member] Deferred Revenue Arrangement [Line Items] Deferred Revenue Arrangement [Line Items] Grants receivable Grants Receivable Funding of grant award Funding Of Grant Award, Cash Received Funding Of Grant Award, Cash Received Milestone payment received on grant award Milestone Payment On Grant Award, Cash Received Milestone Payment On Grant Award, Cash Received Progress payment received on grant award Progress Payment On Grant Award, Cash Received Progress Payment On Grant Award, Cash Received CIRM upfront funding - current Accrued Grant Funding Accrued Grant Funding Amortization of accrued grant funding to offset expense Amortization Of Accrued Grant Funding Liability To Offset Expense Amortization Of Accrued Grant Funding Liability To Offset Expense Research Funding Research, Development, and Computer Software Disclosure [Text Block] Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Subsidiary, Sale of Stock [Axis] Sale of Stock [Axis] Sale of Stock, Name of Transaction [Domain] Sale of Stock [Domain] Lincoln Park Agreement Lincoln Park Agreement [Member] Lincoln Park Agreement [Member] H.C. Wainwright Sales Amended Agreement H.C. Wainwright Sales Amended Agreement [Member] H.C. Wainwright Sales Amended Agreement [Member] Class of Stock [Line Items] Class of Stock [Line Items] Aggregate offering amount authorized per agreement Sale Of Stock, Aggregate Offering Amount Authorized Per Agreement Sale Of Stock, Aggregate Offering Amount Authorized Per Agreement Commitment shares issued as consideration per agreement (shares) Stock Issued During Period, Shares, Issued As Consideration Stock Issued During Period, Shares, Issued As Consideration Number of shares sold (shares) Sale of Stock, Number of Shares Issued in Transaction Price of shares sold (in dollars per share) Sale of Stock, Price Per Share Gross price for stock transaction Sale of Stock, Consideration Received on Transaction Term of agreement (in months) Term Of Agreement Term Of Agreement Number of shares allowable to direct for Regular Purchase (shares) Sale Of Stock, Amount Per Agreement, Allowable To Direct Counterparty To Purchase, Regular Purchase Sale Of Stock, Amount Per Agreement, Allowable To Direct Counterparty To Purchase, Regular Purchase Maximum obligation per directed purchase transaction for Regular Purchase Sale Of Stock, Maximum Amount Per Agreement Per Transaction For Direct Counterparty Purchase, Regular Purchase Sale Of Stock, Maximum Amount Per Agreement Per Transaction For Direct Counterparty Purchase, Regular Purchase Maximum shares allowed in Accelerated Purchase as percent of shares in Regular Purchase (percent) Sale Of Stock, Maximum Shares Allowed In Accelerated Purchase As Percent Of Shares In Regular Purchase Sale Of Stock, Maximum Shares Allowed In Accelerated Purchase As Percent Of Shares In Regular Purchase Maximum shares allowed in Accelerated Purchase as percent of shares traded during specified period (percent) Sale Of Stock, Maximum Shares Allowed In Accelerated Purchase As Percent Of Shares Of Stock Traded During Specified Period Sale Of Stock, Maximum Shares Allowed In Accelerated Purchase As Percent Of Shares Of Stock Traded During Specified Period Maximum beneficial ownership allowable per agreement (percent) Registration Rights Agreement, Maximum Beneficial Ownership Allowable For Counterparty Registration Rights Agreement, Maximum Beneficial Ownership Allowable For Counterparty Aggregate market value of common stock held by non-affiliates Aggregate Market Value Of Common Stock, Non-Affiliates Aggregate Market Value Of Common Stock, Non-Affiliates Maximum number of shares authorized per agreement (shares) Sale Of Stock, Maximum Number Of Shares Authorized Per Agreement Sale Of Stock, Maximum Number Of Shares Authorized Per Agreement Commission on gross proceeds due to third party (percent) Sale Of Stock, Commission On Gross Proceeds Due To Third Party Upon, Percent Sale Of Stock, Commission On Gross Proceeds Due To Third Party Upon, Percent Stock issued (shares) Stock Issued During Period, Shares, New Issues Proceeds from issuance of stock Proceeds from Issuance of Common Stock Statement of Stockholders' Equity [Abstract] Statement [Table] Statement [Table] Statement, Equity Components [Axis] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Total Caladrius Biosciences, Inc. Stockholders' Equity Parent [Member] Series B Convertible Preferred Stock Preferred Stock [Member] Common Stock Common Stock [Member] Additional Paid in Capital Additional Paid-in Capital [Member] Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] Accumulated Deficit Retained Earnings [Member] Treasury Stock Treasury Stock [Member] Non- Controlling Interest in Subsidiary Noncontrolling Interest [Member] Statement [Line Items] Statement [Line Items] Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Beginning Balance (in shares) Shares, Outstanding Beginning Balance Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest Adoption of accounting standard New Accounting Pronouncement or Change in Accounting Principle, Effect of Adoption, Quantification Net loss Unrealized loss on marketable securities Marketable Securities, Unrealized Gain (Loss) Share-based compensation (in shares) Shares Issued, Shares, Share-based Payment Arrangement, after Forfeiture Share-based compensation Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture Net proceeds from issuance of common stock (in shares) Net proceeds from issuance of common stock Stock Issued During Period, Value, New Issues Proceeds from option exercises (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Proceeds from option exercises Stock Issued During Period, Value, Stock Options Exercised Change in ownership in subsidiary Change in Ownership in Subsidiary Change in Ownership in Subsidiary Ending Balance (in shares) Ending Balance Stock Options, Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Outstanding, beginning balance (shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Granted (shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Exercised (shares) Forfeited (shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Expired (shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period Outstanding, ending balance (shares) Vested or expected to vest (shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Exercisable (shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number Stock Options, Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Outstanding, beginning balance (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Forfeited (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Expired (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price Outstanding, ending balance (in dollars per share) Vested or expected to vest (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Exercisable (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price Stock Options, Weighted Average Contractual Term and Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] Stock options outstanding, weighted average remaining contractual term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Stock options vested or expected to vest, weighted average remaining contractual term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Stock options exercisable, weighted average remaining contractual term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term Stock options outstanding, aggregate intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Stock options exercisable, aggregate intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value Stock options vested or expected to vest, aggregate intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Warrants, Shares Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Warrants outstanding, beginning balance (shares) Common Stock Warrants, Shares Common Stock Warrants, Shares Warrants granted (shares) Warrants Granted Warrants Granted Warrants exercised (shares) Warrants Exercised Warrants Exercised Warrants forfeited (shares) Warrants Canceled Warrants Canceled Warrants expired (shares) Warrants Expired Warrants Expired Warrants outstanding, ending balance (shares) Warrants vested or expected to vest (shares) shares, vested and expected to vest shares, vested and expected to vest Warrants exercisable (shares) Warrants, Vested Warrants, Vested Warrants, Weighted Average Exercise Price Warrants Weighted Average Exercise Price [Roll Forward] Warrants Weighted Average Exercise Price [Roll Forward] Warrants outstanding, beginning balance (in dollars per share) Weighted Average Exercise Price, Warrants Outstanding Weighted Average Exercise Price, Warrants Outstanding Warrants granted (in dollars per share) Weighted Average Exercise Price, Warrants Granted Weighted Average Exercise Price, Warrants Granted Warrants exercised (in dollars per share) Weighted Average Exercise Price, Warrants Exercised Weighted Average Exercise Price, Warrants Exercised Warrants forfeited (in dollars per share) Weighted Average Exercise Price, Warrants Canceled Weighted Average Exercise Price, Warrants Canceled Warrants expired (in dollars per share) Weighted Average Exercise Price, Warrants Expired Weighted Average Exercise Price, Warrants Expired Warrants outstanding, ending balance (in dollars per share) Warrants vested or expected to vest (in dollars per share) Weighted Average Exercise Price, Warrants Vested And Expected To Vest Weighted Average Exercise Price, Warrants Vested And Expected To Vest Warrants exercisable (in dollars per share) Weighted Average Exercise Price, Warrants Exercisable Weighted Average Exercise Price, Warrants Exercisable Warrants, Weighted Average Contractual Term and Intrinsic Value Warrants Other Disclosures [Abstract] Warrants Other Disclosures [Abstract] Warrants outstanding, weighted average remaining contractual term (in years) Weighted Average Remaining Contractual Term warrant outstanding Weighted Average Remaining Contractual Term warrant outstanding Warrants vested or expected to vest, weighted average remaining contractual term (in years) Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest Warrants exercisable, weighted average remaining contractual term (in years) weighted Average Remaining Contractual Term, warrants vested weighted Average Remaining Contractual Term, warrants vested Warrants outstanding, aggregate intrinsic value Aggregate Intrinsic Value, Warrants Outstanding Aggregate Intrinsic Value, Warrants Outstanding Warrants vested or expected to vest, aggregate intrinsic value Aggregate Intrinsic Value, Warrants vested and expected to vest Aggregate Intrinsic Value, Warrants vested and expected to vest Warrants exercisable, aggregate intrinsic value Aggregate Intrinsic Value, Warrants vested Aggregate Intrinsic Value, Warrants vested Investments, Debt and Equity Securities [Abstract] Schedule of Available-for-sale Securities [Table] Schedule of Available-for-sale Securities [Table] Financial Instrument [Axis] Financial Instrument [Axis] Financial Instruments [Domain] Financial Instruments [Domain] Corporate debt securities Corporate Debt Securities [Member] Money market funds Money Market Funds [Member] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-sale [Line Items] Cost Debt Securities, Available-for-sale, Amortized Cost Gross Unrealized Gains Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Gross Unrealized Losses Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Estimated Fair Value Debt Securities, Available-for-sale Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Measurement Frequency [Axis] Measurement Frequency [Axis] Measurement Frequency [Domain] Measurement Frequency [Domain] Recurring Fair Value, Recurring [Member] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Level 1 Fair Value, Inputs, Level 1 [Member] Level 2 Fair Value, Inputs, Level 2 [Member] Level 3 Fair Value, Inputs, Level 3 [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Assets: Assets, Fair Value Disclosure [Abstract] Marketable securities - available for sale Investments, Fair Value Disclosure Assets - fair value Assets, Fair Value Disclosure Share-based Payment Arrangement [Abstract] Stock Options Share-based Payment Arrangement, Option [Member] Unrecognized compensation cost Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Expected weighted-average period in years of compensation cost to be recognized Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] The Business The Business [Text Block] The Business [Text Block] Effective Income Tax Rate Reconciliation, Amount [Abstract] Effective Income Tax Rate Reconciliation, Amount [Abstract] U.S. Federal benefit at statutory rate Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount State and local (benefit) / expense net of U.S. federal tax Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount Permanent non deductible expenses for U.S. taxes Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount AMT credit benefit Effective Income Tax Rate Reconciliation, Tax Credit, Other, Amount Change in state deferred Effective Income Tax Rate Reconciliation, Change in State Deferred, Amount Effective Income Tax Rate Reconciliation, Change in State Deferred, Amount Return to actual Effective Income Tax Rate Reconciliation, Prior Year Income Taxes, Amount Other true ups Effective Income Tax Rate Reconciliation, Other Adjustments, Amount Effect of change in deferred tax rate Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount Valuation allowance for deferred tax assets Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount Tax provision benefit Income Tax Expense (Benefit) Statement of Financial Position [Abstract] Preferred Stock Preferred Stock, Number of Shares, Par Value and Other Disclosures [Abstract] Preferred stock, shares authorized (shares) Preferred Stock, Shares Authorized Preferred stock, liquidation preference (shares) Preferred Stock, Liquidation Preference, Share Preferred Stock, Liquidation Preference, Share Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Preferred stock, shares designated (shares) Preferred stock, shares designated Preferred stock, shares designated Preferred stock, shares issued (shares) Preferred Stock, Shares Issued Preferred stock, shares outstanding (shares) Preferred Stock, Shares Outstanding Common Stock Common Stock, Number of Shares, Par Value and Other Disclosures [Abstract] Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Common stock, shares authorized (shares) Common Stock, Shares Authorized Common stock, shares, issued (shares) Common Stock, Shares, Issued Common stock, shares, outstanding (shares) Common Stock, Shares, Outstanding Treasury Stock Treasury Stock, Number of Shares and Restriction Disclosures [Abstract] Treasury stock (shares) Treasury Stock, Shares Future Minimum Lease Payments Lessee, Operating Lease, Liability, Payment, Due [Abstract] 2020 Lessee, Operating Lease, Liability, Payments, Due Next Twelve Months 2021 Lessee, Operating Lease, Liability, Payments, Due Year Two 2023 Lessee, Operating Lease, Liability, Payments, Due Year Three 2024 Lessee, Operating Lease, Liability, Payments, Due Year Four Total lease payments Lessee, Operating Lease, Liability, Payments, Due Less: Amounts representing interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Present value of lease liabilities Available-for-Sale-Securities Cash, Cash Equivalents, and Marketable Securities [Text Block] Operating Leases Lessee, Operating Leases [Text Block] Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Concentration of Risks Concentration Risk, Credit Risk, Policy [Policy Text Block] Marketable Securities Marketable Securities, Policy [Policy Text Block] Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Long-lived Assets Property, Plant and Equipment, Impairment [Policy Text Block] Share-Based Compensation Share-based Payment Arrangement [Policy Text Block] Loss Per Share Earnings Per Share, Policy [Policy Text Block] Treasury Stock Treasury Stock, Policy [Policy Text Block] Treasury Stock, Policy [Policy Text Block] Research and Development Costs Research and Development Expense, Policy [Policy Text Block] New Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Schedule of Share-based Compensation Expense Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Schedule of Fair Value of Shares Vested and Weighted Average Estimated Fair Values of Shares Granted Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block] Schedule of Assumptions in Calculating Fair Values of Stock Options Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Earnings Per Share [Abstract] Schedule of Antidilutive Securities Excluded from Computation of Loss Per Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Accrued Liabilities Accounts Payable and Accrued Liabilities Disclosure [Text Block] U.S. federal corporate income tax rate (percent) Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Net operating loss carryforwards Operating Loss Carryforwards Market capitalization used in net operating loss analysis Market Capitalization Used In Net Operating Loss Analysis Market Capitalization Used In Net Operating Loss Analysis Limitation on loss carryforward based Section 382 change in ownership Operating Loss Carryforward, Limitation Based On Change In Ownership Operating Loss Carryforward, Limitation Based On Change In Ownership Schedule of Stock Options and Warrants Activity Share-based Payment Arrangement, Option, Activity [Table Text Block] Schedule of Restricted Stock Nonvested Restricted Stock Shares Activity [Table Text Block] Schedule of Restricted Stock Units Share-based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block] Cover page. Document Type Document Type Document Period End Date Document Period End Date Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Amendment Flag Amendment Flag Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Voluntary Filers Entity Interactive Data Current Entity Interactive Data Current Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Shell Company Entity Shell Company Entity Public Float Entity Public Float Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding ASSETS Assets [Abstract] Current Assets Assets, Current [Abstract] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Marketable securities Marketable Securities Prepaid and other current assets Prepaid Expense and Other Assets, Current Total current assets Assets, Current Property and equipment, net Property, Plant and Equipment, Net Other assets Other Assets, Noncurrent Total assets Assets LIABILITIES, NON-CONTROLLING INTERESTS AND EQUITY Liabilities and Equity [Abstract] Liabilities Liabilities, Current [Abstract] Accounts payable Accounts Payable, Current Accrued liabilities Accrued Liabilities, Current Total current liabilities Liabilities, Current Other long-term liabilities Other Liabilities, Noncurrent Total liabilities Liabilities Commitments and Contingencies Commitments and Contingencies Stockholders' Equity Stockholders' Equity Attributable to Parent [Abstract] Preferred stock; authorized, 20,000,000 shares Series B convertible redeemable preferred stock liquidation value, 0.001 share of common stock, $.01 par value; 825,000 shares designated; issued and outstanding, 10,000 shares at December 31, 2019 and December 31, 2018, respectively Preferred Stock, Value, Issued Common stock, $.001 par value, authorized 500,000,000 shares; issued and outstanding, 10,528,689 and 9,865,735 shares, at December 31, 2019 and December 31, 2018, respectively Common Stock, Value, Issued Additional paid-in capital Additional Paid in Capital Treasury stock, at cost; 11,080 shares at December 31, 2019 and December 31, 2018 respectively Treasury Stock, Value Accumulated deficit Retained Earnings (Accumulated Deficit) Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax Total Caladrius Biosciences, Inc. stockholders' equity Stockholders' Equity Attributable to Parent Noncontrolling interests Stockholders' Equity Attributable to Noncontrolling Interest Total equity Liabilities and Equity, Total Liabilities and Equity Subsequent Events [Abstract] Subsequent Events Subsequent Events [Text Block] Leasehold improvements Leasehold Improvements [Member] Property, Plant and Equipment, Net, by Type [Abstract] Property, Plant and Equipment, Net, by Type [Abstract] Property and equipment, gross Property, Plant and Equipment, Gross Accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Property and equipment, net Depreciation expense Depreciation, Depletion and Amortization Schedule of Available-for-Sale Securities Reconciliation Schedule of Available-for-sale Securities Reconciliation [Table Text Block] Schedule of Marketable Securities Marketable Securities [Table Text Block] Schedule of Available-for-Sale Securities by Contractual Maturity Investments Classified by Contractual Maturity Date [Table Text Block] Loss Per Share Earnings Per Share [Text Block] Schedule of Fair Value of Assets Measured on Recurring Basis Fair Value, Assets Measured on Recurring Basis [Table Text Block] Amortized Cost Debt Securities, Available-for-sale, Amortized Cost, Fiscal Year Maturity [Abstract] Less than one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, within One Year, Amortized Cost Greater than one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, after One Through Five Years, Amortized Cost Estimated Fair Value Debt Securities, Available-for-sale, Fair Value, Fiscal Year Maturity [Abstract] Less than one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, within One Year, Fair Value Greater than one year Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, after One Through Five Years, Fair Value Estimated fair value Components of Deferred Tax Assets and Liabilities [Abstract] Components of Deferred Tax Assets and Liabilities [Abstract] Deferred Tax Assets: Deferred Tax Assets, Gross [Abstract] Accumulated net operating losses (tax effected) Deferred Tax Assets, Operating Loss Carryforwards CIRM funding Deferred Tax Assets, Deferred Income Right of use liability Deferred Tax Assets, Right Of Use Liability Deferred Tax Assets, Right Of Use Liability Share-based compensation Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost Intangibles Deferred Tax Assets, Goodwill and Intangible Assets Charitable contributions Deferred Tax Assets, Charitable Contribution Carryforwards Accumulated depreciation Deferred Tax Assets, Accumulated Depreciation Deferred Tax Assets, Accumulated Depreciation Accrued payroll Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Employee Compensation Other Deferred Tax Assets, Other Deferred tax assets Deferred Tax Assets, Gross Deferred Tax Liabilities: Deferred Tax Liabilities, Gross [Abstract] Right of use asset Deferred Tax Liabilities, Leasing Arrangements Deferred tax liabilities Deferred Tax Liabilities, Gross Net deferred tax asset, before valuation allowance Deferred Tax Assets, Net Valuation allowance Deferred Tax Assets, Valuation Allowance Net deferred tax asset Deferred Income Tax Assets, Net Share-Based Compensation Share-based Payment Arrangement [Text Block] Other assets Other Assets [Member] Accrued liabilities Accrued Liabilities [Member] Other long-term liabilities Other Noncurrent Liabilities [Member] Balance Sheet Assets and Liabilities, Lessee [Abstract] Operating lease liabilities, current Operating Lease, Liability, Current Operating lease liabilities, noncurrent Operating Lease, Liability, Noncurrent Total fair value of shares vested Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value Weighted average estimated fair value of shares granted (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Salaries, employee benefits and related taxes Employee-related Liabilities Operating lease liabilities - current Other Other Accrued Liabilities, Current Accrued liabilities Accrued Liabilities Plan Name [Axis] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] 2018 Plan Equity Incentive Compensation Plan 2018 [Member] Equity Incentive Compensation Plan 2018 [Member] ESPP Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] 2012 ESPP Employee Stock Purchase Plan 2012 [Member] Employee Stock Purchase Plan 2012 [Member] 2017 ESPP Employee Stock Purchase Plan 2017 [Member] Employee Stock Purchase Plan 2017 [Member] Amended 2017 ESPP Employee Stock Purchase Plan 2017 Amended [Member] Employee Stock Purchase Plan 2017 Amended [Member] Vesting [Axis] Vesting [Axis] Vesting [Domain] Vesting [Domain] Share-based award tranche one Share-based Payment Arrangement, Tranche One [Member] Share-based award tranche two Share-based Payment Arrangement, Tranche Two [Member] Share-based award tranche three Share-based Payment Arrangement, Tranche Three [Member] Number of shares authorized for issuance Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Expiration period (in years) Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Number of shares available for future grant Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Number of offering periods Number of Offering Periods, Employee Stock Purchase Plan Number of Offering Periods, Employee Stock Purchase Plan Term of offering period Offering Periods, Employee Stock Purchase Plan, Term Offering Periods, Employee Stock Purchase Plan, Term Maximum annual contribution per employee as percent of annual salary Employee Stock Purchase Plan, Maximum Annual Contribution Per Employee, Percent Employee Stock Purchase Plan, Maximum Annual Contribution Per Employee, Percent Maximum annual contribution per employee Employee Stock Purchase Plan, Maximum Annual Contribution Per Employee Employee Stock Purchase Plan, Maximum Annual Contribution Per Employee Purchase price measurement as percent of closing price on enrollment date Employee Stock Purchase Plan, Purchase Price, Percent Of Closing Price On Enrollment Date Employee Stock Purchase Plan, Purchase Price, Percent Of Closing Price On Enrollment Date Purchase price measurement as percent of closing price on exercise date Employee Stock Purchase Plan, Purchase Price, Percent Of Closing Price On Exercise Date Employee Stock Purchase Plan, Purchase Price, Percent Of Closing Price On Exercise Date Shares issued under ESPP Stock Issued During Period, Shares, Employee Stock Purchase Plans Schedule of Loss Before Income Tax Provision Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Schedule of Reconciliation of Effective Income Taxes Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Schedule of Components Deferred Income Taxes Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Statement of Cash Flows [Abstract] Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Equity-based compensation expense Issuance of Stock and Warrants for Services or Claims Depreciation and amortization Depreciation, Depletion and Amortization, Nonproduction Gain on disposal of assets Gain (Loss) on Disposition of Assets Amortization/accretion on marketable securities Accretion Expense Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Prepaid and other current assets Increase (Decrease) in Prepaid Expense and Other Assets Other assets Increase (Decrease) in Other Operating Assets Accounts payable, accrued liabilities and other liabilities Increase Decrease In Accounts Payable Accrued Expenses And Other Liabilities Increase Decrease In Accounts Payable Accrued Expenses And Other Liabilities Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Purchase of marketable securities Payments to Acquire Marketable Securities Sales of marketable securities Proceeds from Sale and Maturity of Marketable Securities Proceeds from CFC device sale Proceeds from Sale of Machinery and Equipment Acquisition of property and equipment Payments to Acquire Property, Plant, and Equipment Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Investing Activities Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Proceeds from exercise of options Proceeds from Stock Options Exercised Tax withholding payments on net share settlement equity awards Payment, Tax Withholding, Share-based Payment Arrangement Net proceeds from issuance of capital stock Proceeds from Issuance or Sale of Equity Repayment of notes payable Repayments of Notes Payable Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Net increase (decrease) in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Cash and cash equivalents at beginning of year Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash and cash equivalents at end of year Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Supplemental Disclosure of Cash Flow Information: Supplemental Cash Flow Information [Abstract] Interest Interest Paid, Excluding Capitalized Interest, Operating Activities Taxes Income Taxes Paid Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Warrants Warrant [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Securities excluded from computation of loss per share Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Research and development Research and Development Expense [Member] General and administrative General and Administrative Expense [Member] Share-based Compensation [Line Items] Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Share-based compensation expense Share-based Payment Arrangement, Expense Valuation Assumptions Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract] Expected term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Expected volatility - minimum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum Expected volatility - maximum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum Weighted Average volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Volatility Rate Expected dividend yield Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Risk-free interest rate - minimum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum Risk-free interest rate - maximum Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum Loss before before benefit from income taxes and noncontrolling interests, domestic Income (Loss) from Continuing Operations before Income Taxes, Domestic Loss before benefit from income taxes and noncontrolling interests Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Cash and cash equivalents Restricted Cash and Investments, Current Total Cash, Cash Equivalents, and Short-term Investments Statement of Comprehensive Income [Abstract] Other comprehensive loss: Other Comprehensive Income (Loss), Net of Tax [Abstract] Available for sale securities - net unrealized income (loss) Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax Total other comprehensive income (loss) Other Comprehensive Income (Loss), Net of Tax Comprehensive loss Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest Comprehensive income (loss) attributable to noncontrolling interests Comprehensive Income (Loss), Net of Tax, Attributable to Noncontrolling Interest Comprehensive loss attributable to Caladrius Biosciences, Inc. common stockholders Comprehensive Income (Loss), Net of Tax, Attributable to Parent